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Vendor : HP
Exam Code : HP0-J17
Exam Name : Designing and Implementing the HP StorageWorks EVA4400
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HP0-J17 Designing and Implementing the HP StorageWorks EVA4400

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Designing and Implementing the

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HP0-J17">The vigour of Incentives: training learned from Designing and implementing outcomes-based WASH programs | killexams.com real questions with brain dumps

The power of Incentives: training learned from Designing and implementing consequences-based WASH courses. with the aid of  by way of Elynn Walter, man Howard, Jan Willem Rosenboom, Jeff Albert, Susan Davis, Yi Wei. WASHfunders weblog, November 2017.

This week we spotlight instructions by using UK branch for international building (DFID), bill & Melinda Gates foundation, iDE  and Thrive Networks in designing and implementing  ingenious effects-primarily based WASH classes.

source: Thrive Networks

On September twentieth in new york city, enrich overseas and IRC convened a dialog on innovations in grantee-donor relationships in WASH classes hosted via the Voss foundation and the flora and fauna Conservation Society at their offices next to the primary Park Zoo. This week on the weblog we summarize key takeaways from the meeting.

payment by using outcomes man Howard from the united kingdom’s department for international construction (DFID) introduced on the Water, Sanitation and Hygiene outcomes programme. WASH consequences is a 12-nation payment by using outcomes software involving three employer contracts. funds are made with the aid of DFID following impartial verification of consequences fulfillment. The software is supported with the aid of a monitoring, verification and contrast part which provides unbiased verification of suppliers’ effects achievement, and contains an assessment component including a randomized handle trial on program sustainability.

heritage DFID desired to promptly attain 6 to 7 million people with water access, and so crucial to expand its business enterprise base (in the past, 60% of their water programs had been implemented by UNICEF).  This became the primary time DFID tried charge via outcomes at this scale.

merits NGOs began the usage of robust hybrid monitoring techniques that had been enter- and output-based, with third birthday party verification. All suppliers worked neatly, and favored this components.  PBR has elevated to different programs.

Challenges  businesses deserve to have an asset base to tackle risk as a result of they handiest get paid on the conclusion. Most big non-earnings do have this, however it is determined apart for contingency funding. DFID’s partners had to negotiate with their boards to be capable of access these funds. Few individuals have the competencies (WASH and auditing) to do verification. additionally, because the effects are time-confined they need proxies to measure the power and sustainability of systems.

study the comprehensive article.

Filed under: economic advantages Tagged: incentives

HP0-J17">Testimony on enforcing the 21st Century cures Act: An update from FDA and NIH | killexams.com real questions with brain dumps

Witness performing earlier than the residence Committee on power and Commerce Subcommittee on health

Francis S. Collins, M.D., Ph.D.Director, countrywide Institutes of fitness

Chairman Burgess, rating Member green, uncommon participants of this Subcommittee, thank you for internet hosting this vital listening to. 

extra so, thank you for creating the want for this listening to – for the 21st Century cures Act (treatments Act) which turned into enacted one year in the past.  The remedies Act touches on so many critical issues.  From featuring guide for 4 cutting edge analysis priorities, to improving privacy protections to inclusion of various communities in analysis trials, to reducing administrative burden to expanded prize authority, we at NIH admire your management and dedication in enacting new authorities to velocity the pace of research and enhance how science is carried out to seriously change the manner we translate discovery into remedies. 

In my testimony, i'll highlight how NIH is imposing one of the most key provisions of the remedies Act and how it's benefiting the biomedical analysis community and, most importantly, sufferers.

huge statistics:  The Promise of records Sharing Balanced With the want for privateness

As in most fields, computing vigour is changing the style research is accomplished.  The promise of big information can not be overstated for finding patterns of disorder and health and concentrated on therapeutics to sub-populations.  The Congress, within the remedies Act, wisely identified both the skills and the dangers inherent in sharing statistics sets and NIH has moved instantly to get the acceptable protections in area. 

First, on September seventh, NIH issued a e book note to our research neighborhood implementing the huge enhancements this Committee made to the Certificates of Confidentiality, making them both computerized and compulsory.  To put in force this change whereas minimizing the burden to our researchers, we streamlined the issuance of Certificates into the phrases and prerequisites of each analysis award we make involving human subjects.1  considering that October 1st, each NIH award has this introduced layer of insurance plan for analysis individuals. 

2d, on September 17th, guidance on the FOIA exemption for genomic tips changed into disseminated to all NIH FOIA officers.

only now that the new remedies Act privateness protections are in location, are we moving forward on the unique new authority to require records sharing.  This should be a sea change in biomedical analysis so we need to be deliberate about the way to measure the usefulness of information units, where shared facts should still be stored, how patient protections are insured, how interoperability is completed, and what equipment researchers most want in the shared ambiance.  On November sixth, NIH made 12 awards in a knowledge Commons Pilot to answer simply these kind of questions.  We chosen three well known NIH datasets researchers can use to test their approaches.  The biomedical analysis neighborhood will be staring at this pilot software very intently.       


We’ve made giant growth in managing ailments during the construction of new medication and instruments through the years that were validated in medical trials.  but trials haven’t at all times blanketed the total spectrum of humanity, and this limits the applicability of examine effects.  It additionally limits our potential to goal remedies and handle disparities.  Congress helped NIH tackle this difficulty in the course of the remedies Act in three focal point areas:  inclusion of toddlers and seniors; inclusion of pregnant and lactating ladies; and continuing our focus on women, and racial and ethnic minorities. 

On June 1-2, 2017, as required through the treatments Act, NIH held a workshop on inclusion across the lifespan.  It could seem to be handy to include all age ranges however each little ones and older adults require particular concerns.  on the workshop, investigators with competencies in conducting clinical studies with pediatric and older populations, ethics experts, and other stakeholders had a strong discussion about limitations and facilitators to the inclusion of volunteers of all a long time in research.  The findings and recommendations could be offered at my Advisory Committee assembly on December 14-15, 2017, and we can determine what coverage alterations are mandatory to be sure people throughout the lifespan are correctly included in medical analysis.

The remedies Act additionally asks NIH to proceed making development on the inclusion of girls and ethnic and racial minority populations in analysis.  This has been a partnership of the Congress and NIH for a long time – the Congress licensed each the NIH workplace of analysis on ladies’s health and what is now the country wide Institute on Minority fitness and health Disparities in 1993.  With the help of the Congress and the remedies Act, we proceed to enrich.  We are actually collecting inclusion records on a analyze-by-study basis and in the coming 12 months NIH will document, for the first time, inclusion facts from reviews on a ailment and circumstance basis.  on the December assembly, the expert Advisory Committee can have a public discussion of innovations for extra advancing the container and updating our inclusion guidelines.  I appear forward to the dialog and that i could be chuffed to update you as selections are made. 

finally, the remedies Act created a job force on research particular to Pregnant women and Lactating girls (PRGLAC) to propose the Secretary of fitness and Human functions related to gaps in competencies and analysis on secure and beneficial healing procedures for pregnant ladies and lactating girls.2  This area of research is a must-have, however it is fully crucial that we carefully consider intentional exposures during this potentially vulnerable time of existence.  NIH dependent PRGLAC on March 13, 2017, bringing together federal and non-federal consultants, including the meals and Drug Administration, representatives from central scientific societies, non-profit corporations, and trade, to focus on these vital concerns.

PRGLAC has already held two conferences – the primary on August 21-22, 2017, to assess the scope of latest Federal actions on secure and constructive therapies for pregnant and lactating ladies, and the 2nd on November 6-7, 2017, to take note the moral concerns surrounding research to boost treatments for pregnant and lactating girls.  The third meeting on February 26-27, 2018, can be on communique innovations for health care providers and the public concerning the use of healing procedures for pregnant and lactating girls, and the fourth assembly on can also 14-15, 2018, should be on options to tackle the gaps in capabilities, ethical considerations, and communication ideas for treatments used via pregnant and lactating ladies. 

in line with the effect of the assignment drive meetings, a file with strategies can be developed for the HHS Secretary.  NIH is grateful to the Congress for recognizing the want for careful consideration in this area of research and looks ahead to addressing any recommendations made by way of the project force.

Strengthening Biomedical team of workers

NIH and its stakeholder neighborhood have for a long time been involved about the long-time period steadiness of the biomedical analysis enterprise.  as a consequence of NIH’s lack of more than 20 percent of its paying for vigour from 2003 to 2015, researchers had been compelled to vie for restrained materials, resulting in a hypercompetitive atmosphere.  With success quotes beneath 20 percent, many highly meritorious purposes proceed to move unfunded.   This has too frequently resulted in misaligned incentives and unintended penalties for gifted researchers in any respect profession stages who are attempting to be triumphant and live in science.  The existing environment is principally challenging for many new- and mid-career investigators.

Over the ultimate several years, NIH has taken a large number of steps to steadiness, reinforce, and stabilize the biomedical analysis team of workers, however these measures have only taken us to this point.  whereas the percent of NIH awards that assist early-profession investigators has gone from declining to flat, these positive factors had been offset via a decline in the percentage of NIH awards that aid mid-career investigators. 

As an instantaneous effect of the remedies Act, in June 2017, NIH launched the subsequent era Researchers Initiative3 aimed at strengthening the biomedical staff with a focus on early profession investigators or investigators who're at an early stage in their career.  NIH intends to take a multi-pronged approach, which we outlined in an editorial published on November 7, 2017,4 to raise the variety of NIH-funded early-stage and mid-career investigators and to stabilize the profession trajectory of scientists.

NIH will improve evidence-based mostly, facts-driven options to guarantee that NIH investments are directed in ways in which maximize scientific output.  Institutes and centers will also place improved emphasis on present NIH funding programs to identify, develop, and keep new- and mid-profession investigators across these critical profession tiers.  The NIH office of the Director will music development across ICs and assess if these innovations are working.  i am in my view dedicated to this difficulty and thank the Committee for his or her support of early- and mid-career investigators.

device Innovation:  decreasing Administrative Burden and increasing effectivity

policies generated with the greatest intentions sometimes have critical adversarial consequences for analysis.  The remedies Act included a large number of provisions that cut the bureaucratic purple tape that slows the progress of science.  It also supplied NIH with new authorities to enrich efficiencies and pace up the invention manner. 

The treatments Act covered provisions to enhance ClinicalTrials.gov.  ClinicalTrials.gov is a database of privately and publicly funded medical experiences carried out all over the world that plays a crucial position in guaranteeing the transparency and accountability to the public of researchers and their sponsors.  additionally, this resource is used by way of researchers to reside up-to-date on tendencies of their box, locate collaborators, and determine unmet wants, and it's additionally used with the aid of sufferers and households to look for talents reviews to join or find out about new cures which are being demonstrated.  NIH strives to make this resource as user friendly as possible so it may well improvement researchers, patients, and their households, and the treatments Act is assisting in several methods. 

First, the cures Act made technical fixes to the law establishing ClinicalTrials.gov that make sure NIH is able to trap extra scientific trials in the gadget and increase our oversight and transparency.  second, it required NIH to discuss with crucial Federal businesses and other stakeholders to receive strategies to increase ClinicalTrials.gov’s usability, functionality, and search ability.  In February 2017, the countrywide Library of medication (NLM), along with 18F, a digital capabilities consultancy inside the familiar services Administration, began conducting consumer research on ClinicalTrials.gov with a range of stakeholders.  on account of this work, NIH rolled out a primary in a sequence of changes to ClinicalTrials.gov on June 19, 2017.  On September 25, 2017, NLM released extra updates because the subsequent section in its ongoing effort to enhance the functionality of the database.  according to the treatments Act, NLM will work consistently to make it less difficult for users to discover and participate in medical trials.

so as to enrich effectivity, the treatments Act offered a new EUREKA prize authority and allowed NIH to use different Transactions Authority (OTA) in two areas that want extra flexibility and collaboration:  the general Fund and the anyone analysis program, part of the NIH Precision drugs Initiative.  

The EUREKA prize authority is being carried out in 3 ways:

  • On November 2nd, the national Institute on getting old issued a request5 for public input on (1) the feasibility of three advantage prize competitions focused on Alzheimer’s disease (advert) and connected dementias (ADRD):  Validating predictors of advert progression; PET radiotracer to measure in vivo synaptic integrity; and least expensive innovation of enhancing techniques of take care of advert/ADRD patients and caregivers; and (2) any other information on advert/ADRD research desires to hook up with a prize.  feedback are due on December 31, 2017.  
  • NIH fashioned the EUREKA Prize Coordination Committee to overview future proposals for future EUREKA prize competitions. 
  • NIH funded the countrywide Academy of Sciences (NAS) to analyze Innovation Prizes and Federal R&D with certain emphasis on ideas to examine which “EUREKA” prize themes are per congressional intent.  The NAS look at will additionally consider the strengths and weaknesses of a variety of measures of fitness effects and effects on government charges.  The NAS intends to hang a workshop in 2018. 
  • OTA is indispensable to our exploration of how gold standard to structure facts sharing, widespread as the records Commons Pilot part,6 which became announced on November sixth.  The purpose of the NIH records Commons is to accelerate new biomedical discoveries by using providing a cloud-based mostly platform the place investigators can shop, share, access, and compute on digital objects (statistics, software, etc.) generated from biomedical research and perform novel scientific research including hypothesis technology, discovery, and validation.  using OTA awards allows for flexibility for the awardees to work together to design innovation options that meet the computational and scientific wants of the Pilot.

    The all and sundry research program goals to enroll a million individuals in a decades-long research venture.  That ambitious goal requires flexibility, advanced and dynamic interactions, and ways to interact non-ordinary NIH awardees to advance the mission.  for example, everybody has used OTA to make awards to the Healthcare company agencies to support build the analysis protocols, test enrollment techniques, and compile essential health statistics and biological specimens.

    The cures Act also acknowledges that two of the cornerstones of scientific advancement are rigor in designing and performing scientific research and the ability to breed biomedical research findings.  In fresh years, the scientific neighborhood has develop into privy to the need to improve rigor and reproducibility.  In 2014, NIH labored with scientific publishers to develop a collection of principles and desires that seventy nine publishers have now counseled.  because the remedies Act requires, my Advisory Committee has convened a Working group on Rigor and Reproducibility and they're reviewing the event of the final few years, resulting in the construction of suggestions for a proper policy.  I look forward to updating you as this effort takes form.

    NIH Innovation Fund

    final, but in no way least, the treatments Act supplied multi-12 months funding through the NIH Innovation Fund for 4 totally inventive scientific analysis initiatives:  the Precision medicine Initiative (PMI), the brain research via Advancing creative Neurotechnologies® (brain) Initiative, the melanoma Moonshot, and the Regenerative medicine Innovation task.   As required by using the remedies Act, on March 28th, I solicited thoughts from my Advisory Committee on the way to allocate the funds.  We had a sturdy dialog about each of the initiatives and the Advisory Committee contributors supplied essential suggestions on a way to flow ahead.  on account of that discussion, and conversations with my NIH colleagues, we drafted the NIH Innovation Fund Work Plan,7 which changed into submitted to Congress in September 2017, outlining how the agency will use the NIH innovations cash for each of those four initiatives.  i would like to let you know somewhat about each of these initiatives and how the NIH Innovation cash are assisting to movement every initiative forward.

    The Precision medication Initiative

    Precision medicine is a progressive strategy for disease prevention and remedy that takes into account individual ameliorations in culture, environment, and biology.  whereas some advances in precision medicine had been made, the observe is not in use for most illnesses.  The all people research application, a key point of PMI, is building a countrywide aid—some of the world's biggest, most distinctive biomedical statistics sets in historical past—to accelerate health analysis and clinical breakthroughs, enabling individualized prevention, medication, and care.  everybody will have interaction one million or extra U.S. volunteers from all existence stages, health statuses, races/ethnicities, and geographic regions to mirror the country’s diverse areas and individuals to make contributions their fitness facts over decades to increase fitness consequences, gas the development of new cures for ailment, and catalyze a new period of evidence-based mostly and more genuine preventive care and medical remedy.

    across the nation, NIH has engaged 10 large health issuer companies, six neighborhood health facilities, and the Veterans Administration to be our partners in this bold study.  The application is launching in stages.  The beta part all started in may additionally 2017 right through which every of our partners are trying out their systems and procedures to make certain a fine experience for participants.  

    In July 2017, the program made its first four community associate awards to motivate diverse communities to be a part of and stay within the software, with a focus on those historically underrepresented in biomedical research.  each of those agencies has deep, relied on relationships within and ties to their communities, and we're so very joyful to give you the option to companion with them to boost our outreach into communities that have traditionally been underrepresented in biomedical analysis. NIH has also engaged with companies to create cell apps to sign up, obtain consent from, assemble information from, and talk with anyone participants.  one in all our companions is working with FitBit on a pilot which will start in mid-2018 to verify out techniques for individuals to with no trouble and successfully contribute statistics on actual exercise, sleep, heart rates, and other behavioral fitness advice.

    We count on to roll out nationally in spring 2018.  Following the national launch, we are able to make continuous advancements and updates to the application in response to participant feedback and rising scientific opportunities and technological advances.  The cures Act Innovation money could be essential to making certain the success of absolutely everyone and the promise of personalised medicine.

    The brain® Initiative

    The mind Initiative is aimed at revolutionizing our understanding of the human mind, probably the most complex constitution in the conventional universe.  Launched in 2013, this big-scale effort will push the boundaries of neuroscience research and equip scientists with insights crucial for treating a wide selection of mind disorders.  by using accelerating the development and software of creative applied sciences, researchers might be in a position to produce a progressive new dynamic image of the brain that, for the primary time, suggests how particular person cells and complicated neural circuits engage in each time and house.  long preferred by means of researchers in search of new the way to treat, treatment, and even prevent brain problems, this photograph will fill primary gaps in our existing potential and provide unheard of alternatives for exploring exactly how the mind allows for the human body to checklist, manner, make the most of, save, and retrieve massive quantities of information, all at the pace of notion.

    NIH leveraged the cures Act’s FY 2017 Innovation dollars, moreover our annual appropriation, to launch a hundred and ten wonderful new research projects.8 These tasks are focused on setting up distinctive brain circuit maps and robust new equipment to display screen and modulate brain recreation in animal models to benefit sufferers with neurological and psychiatric issues.  realizing the manner the mind tactics suggestions and the way it lays down memories and retrieves them might be instrumental for realizing brain fitness, and subsequently, preventing brain issues reminiscent of Alzheimer’s sickness, Parkinson’s, schizophrenia, autism, drug addiction, and worrying mind harm.  These awards add to work already underway to provide us a excessive-resolution image of the circuits and networks in the brain, how they work, and the place they can go wrong.

    The cancer Moonshot℠

    The melanoma Moonshot,9 funded within the cures Act, has an ambitious purpose:  to dramatically speed advances in cancer prevention, analysis, medicine, and care.  The country wide cancer Institute (NCI) solicited direct enter from the general public and convened a Blue Ribbon Panel (BRP) of the nation’s correct melanoma researchers, oncologists, affected person advocates, and private-sector leaders.  In September 2016, the BRP introduced its report outlining ten bold and viable techniques to the NCI’s countrywide melanoma Advisory Board. These thoughts form the scientific blueprint of the cancer Moonshot representing areas of analysis that are poised to speed up our understanding of cancer and convey improvement to sufferers. universal, the concepts create a imaginative and prescient for future melanoma analysis and medication through which: 

  • Researchers can determine feasible ambitions for the construction of recent melanoma cures and preventive interventions, together with immunotherapy and immunoprevention, and learn extra about the way to stay away from or overcome cancer drug resistance in sufferers;
  • distinct businesses of sufferers make a contribution counsel about their melanoma, acquire a genomic profile, be trained what treatments might work most effective given their profile, and establish medical trials that may well be applicable for them;
  • Infrastructures are established so that fitness care providers and researchers can share, entry, and analyze suggestions that improves the understanding of how tumors evolve, more desirable predicts medication outcomes, and helps manage patient indicators and side results.
  • Some of those desires are scientific in nature, and some are systemic.  If we're to velocity advances, we cannot readily do more of the identical.  We must transform the way we behavior research, the way we share results, and the way we get discoveries into patient care.  In FY 2017, NIH made 142 melanoma Moonshot awards, together with efforts to leverage advances in immunotherapy, take into account drug resistance, and enhance of new technologies to characterize tumors and look at various treatment options.  These countrywide and overseas collaborations will pressure discovery for melanoma sufferers and their households.  i want to spotlight a kind of collaborations for you today.

    On October 12, 2017, NIH and eleven leading biopharmaceutical companies launched the Partnership for Accelerating melanoma therapies (PACT), a 5-yr public-private analysis collaboration totaling $215 million as part of the melanoma Moonshot.10  PACT will firstly focal point on efforts to establish, strengthen, and validate powerful biomarkers — standardized organic markers of sickness and medicine response — to develop new immunotherapy treatments that harness the immune system to attack cancer.  we have viewed dramatic responses from immunotherapy, regularly eradicating melanoma fully for some melanoma patients.  We need to deliver that form of success — and hope — to greater people with greater forms of cancers, and we should do it immediately.  a scientific strategy like PACT will support us to achieve success sooner.

    With the support of the Congress, the cancer Moonshot will seriously change the manner melanoma research is carried out and confirm that immense development is made for sufferers and their families.

    The Regenerative drugs Innovation task

    Regenerative medication is an emerging enviornment of science that holds exquisite promise for treating and maybe even curing numerous injuries and illnesses.  Regenerative medicine includes using stem cells and other applied sciences, comparable to engineered biomaterials and gene editing — to restoration or exchange broken cells, tissues, or organs.  Stem telephone-based mostly procedures are below construction in labs worldwide, and a few have already moved into scientific trials. Such progress in spite of the fact that, a great deal work remains to be accomplished toward the construction of safe and positive regenerative medication interventions to know the full expertise of this box.

    as a result of the cures Act, NIH launched the Regenerative drugs Innovation task to help medical research on grownup stem cells whereas merchandising the optimum specifications for undertaking scientific research and maintaining affected person safeguard.  The $2 million treatments provided for this initiative in FY 2017 have been amplified through matching money and NIH Institute contributions to attain a total of simply below $5 million.  In September, NIH made eight medical research awards11 that cover a broad spectrum of science and new applied sciences, and have the capabilities to enhance realizing and treatment of common ailments – including diabetes, anemia, corneal and different eye ailments, and chronic epidermis ulcers – in addition to rare diseases, including idiopathic pulmonary fibrosis, inherited dermis illnesses, and sickle mobile disorder.

    several awards will explore using grownup stem cells to make really good cells and tissues that may help reduce the want for total organ transplants or otherwise restoration ordinary characteristic.  Others aim to develop reliable strategies of generating crimson blood cells and platelets within the lab to enrich the security and provide of blood accessible for transfusion.

    NIH appears ahead to the probability the cures Act provides to increase this field of science and is internet hosting a workshop on December 6-7, 2017,12 to discover the state of regenerative medicine science involving grownup stem cells, with a spotlight on tactics for the development of safe and helpful items.  this can assist inform our funding choices in future fiscal years.


    thanks to your management and dedication that resulted in enacting the treatments Act 365 days in the past.  over the last yr, the treatments Act has supplied NIH with vital components and equipment to boost our mission – to are trying to find simple knowledge concerning the nature and behavior of living systems and the application of that potential to increase health, lengthen existence, and in the reduction of affliction and disability.  We respect Congress’s support for NIH during the treatments Act and will proceed to enforce the legislations to accelerate scientific discoveries and advantage patients.

    1 https://humansubjects.nih.gov/coc/index

    2 https://www.nichd.nih.gov/about/advisory/PRGLAC/Pages/index.aspx

    three https://can provide.nih.gov/ngri.htm

    four Michael Lauer, Lawrence Tabak, and Francis Collins, “Opinion: The next era Researchers Initiative at NIH,” PNAS, 114 (2017): 11801-11803.

    5 https://offers.nih.gov/delivers/e-book/note-files/not-AG-17-018.html


    7https://www.nih.gov/websites/default/information/analysis-working towards/initiatives/nih-treatments-innovation-plan.pdf

    8 https://www.braininitiative.nih.gov/funding/fundedAwards.htm

    9 https://www.cancer.gov/analysis/key-initiatives/moonshot-melanoma-initiative


    eleven https://www.nih.gov/rmi/fy-2017-funded-awards

    12https://www.nih.gov/research-working towards/clinical-research-initiatives/remedies

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    References :

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    HP HP0-J17 Exam (Designing and Implementing the HP StorageWorks EVA4400) Detailed Information

    HP0-J17 - Designing and Implementing the HP StorageWorks EVA4400

    HP0-J17 Test Objectives


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