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Cleveland AB R H BI BB SO Avg.
Sizemore cf 4 0 2 0 0 0 .269
JCarroll 2b 2 0 0 0 1 1 .274
BFrancisco lf 4 1 1 0 0 0 .272
Peralta ss four 1 1 2 0 0 .250
Blake 1b 4 0 1 0 0 1 .280
Shoppach c 4 1 1 0 0 1 .265
Garko dh 3 0 1 1 0 0 .244
b-Choo ph 1 0 0 0 0 1 .244
AMarte 3b 3 0 0 0 0 1 .143
FGutierrez rf three 0 0 0 0 1 .218
Totals 32 three 7 3 1 6
Minnesota AB R H BI BB SO Avg.
CaGomez cf 4 0 1 1 0 1 .269
ACasilla 2b four 0 1 1 0 1 .320
Redmond c 4 0 1 0 0 1 .297
Morneau 1b 4 0 0 0 0 0 .307
Monroe dh 2 1 0 0 1 0 .219
a-Kubel ph-dh 1 0 0 0 0 1 .266
DYoung lf 4 1 1 0 0 2 .288
BHarris 3b three 1 1 0 0 0 .250
Punto ss 3 0 1 1 0 0 .289
Span rf 2 1 1 1 1 1 .313
Totals 31 4 7 4 2 7
a-struck out for Monroe in the 8th. b-struck out for Garko within the ninth.
LOB—Cleveland four, Minnesota 5. 2B—Shoppach (12). 3B—Span (1). HR—Peralta (13), off Perkins. RBIs—Peralta 2 (38), Garko (40), CaGomez (30), ACasilla (35), Punto (14), Span (5). S—JCarroll. GIDP—Peralta. Runners left in scoring position—Cleveland 1 (Peralta); Minnesota 2 (ACasilla 2). Runners moved up—CaGomez, ACasilla. DP—Minnesota 1 (Punto, ACasilla and Morneau).
Cleveland IP H R ER BB SO NP era
CLee L, eleven-2 7 6 four four 2 6 108 2.forty three
RBetancourt 1 1 0 0 0 1 15 5.sixty seven
Minnesota IP H R ER BB SO NP period
Perkins W, 5-2 7 7 3 3 1 three ninety seven 4.27
Guerrier 1 0 0 0 0 1 10 three.06
Nathan S, 25 1 0 0 0 0 2 eleven 1.23
Umpires—domestic, Jeff Nelson; First, Adrian Johnson; 2nd, Tim Tschida; Third, Jim Joyce. Time—2:27. Tickets bought—30,258 (46,632).
How they scored
Indians 2d: Blake flied out to correct. Shoppach doubled to appropriate. Garko singled to middle, scoring Shoppach. Marte struck out. Gutierrez grounded out. Indians 1, Twins 0.
Indians sixth: Carroll popped out to 2nd. Francisco singled to left. Peralta homered to left on a 1-0 count, scoring Francisco. Blake infield single to first. Shoppach struck out. Garko grounded out. Indians three, Twins 0.
Twins sixth: Span tripled to middle. Gomez struck out. Casilla grounded out, scoring Span scored. Redmond struck out. Indians three, Twins 1.
Twins seventh: Morneau grounded out. Monroe walked. young infield single to third, Monroe to 2d. Harris singled to right, Monroe to 3rd, younger to 2nd. Punto singled to core, scoring Monroe, young to 3rd, Harris to 2d. Span walked, scoring young, Harris to third, Punto to second. Gomez grounded out, scoring Harris, Punto to 3rd, Span to second. Casilla grounded out. last: Twins 4, Indians three.
WP: Marcos Valenzuela (CG, 10Ks). LP: M. Canelo. C, Nico Pena 2-three, RBI; Alex Puga 2BB, R.
WP: JT Hammer. LP: Aaron corridor. F, JT Hammer 2-5, 2R; Cameron Perez 2-four, 2R, 3RBI, 2B; Josh Feaver 2-3, RBI; Izaiah Moreno 2-4, 2 2B; Johnny Nalbandian 2B. M, EG Walden 2R; Chris Bowe 2B; Hunter Thompson 2B; Matt Blumberg 3B, RBI.
WP: Anthony Flores (7Ks). LP: Greg Olmos. ok, Anthony Flores RBI; Hunter Sassalli RBI.
WP: Ethan Freedenburg. LP: Eli Gastelum. Sv: Hans Brown. I, Chris Gurrola 2B; Brown 2B. S, Josh Mares three-four; Jordan Garcia 2-three; Brian Coria 2-2.
WP: Chris DeFrancesco. LP: Fabian Alvarado. C, Dayton Wisley three-4; Austin Uribe 2-three. DP, probability Benadum 2-three 3B; Nathon Valencia 2-three 2B; Travis Jones 2-2, 2B, RBI; Nick Lopez 3-four, 2RBI; Chris DeFrancesco 2RBI; Cameron Anderson RBI.
TRI-RIVER ATHLETIC convention
WP: Tatum. LP: Whittle. Clo, Miller 2RBI; Allison 2B.
TRI-RIVER ATHLETIC conference
WP: Danielle Lung (8Ks). LP: Taja Felder. CE, Mya Felder 2B. C, Ashley Kincaid 2R; Mackenzie Byrd 3B, 2R, 3RBI; Elaine Caballero 2B.
WP: Brittney Espinosa. LP: Molly Millar (9Ks). C, Samantha Arenas three-4, 2B, 4RBI; Ayleen Gonzalez 2B, 2RBI; Marisa Garza RBI. B, Emily Cazares 3-four; Sugar Gonzales 3-four.
Clovis North 9, Clovis West 5
WP: A. Orr (CG). LP: J Platas. CW, Z Cardozo HR, 3RBI; Julianna Martinez 2-four, 2B; Dani Renteria 2-three. CN, H. Ayerza 3-four, 3R; D Humphrey 2R; M. Avery RBI; S. Freeman HR, 3RBI; H Lusk 2-4.
COUNTY/METRO ATHLETIC conference
WP: Mackenzie Soper (10-5, CG, 5Ks). LP: Liz Santoyo. E, Desiree Reyes 2-three, 2B, 3RBI; Kristen Arias three-four, 2HR, 2B, 3RBI; Kayla Bowen 2-4, 2B; Mackenzie Soper 10HR, 2RBI; Tyra Holly 3R-HR; Jasmine Escalante 2-four, RBI; Nae Nae Hempstead 2-3, RBI.
WP: Kaylee Dawson (8Ks). LP: Valerie Ruiz. M, Kaylee Dawson RBI; Tea Layne RBI.
WP: Serena Thompkins (9Ks). LP: G. Saldana (4Ks). H, G. Scalzo 2B. M, Victoria Hernandez 2-four, 2R; Breanna Montoya four-four, 3R, 2B; Kameron Chavez 2-4; Fatima Bakri three-4, 3RBI; Alyssa Montoya 2-2.
WP: Sofia Garcia. LP: destiny Lewis. F, Vanessa Moffat 2-4, 2B, HR 2RBI; Kayla Blue 3B, 2RBI.
WP: Vanessa Ortiz (CG). LP: Alex Snyder (CG). S, Nevaeh Davalos 2-4, 2B, 3RBI; Atzeli Ramirez 2-three; Ashely Quijada RBI. R, Emma Mulligan 3-4, HR (2-run), 3RBI, run; want Acosta 2-4, 2B, 2 runs; Aryana Gonzalez 2B, RBI; Lala Mendoza Sac Fly, RBI.
WP: Faby Hernandez. LP: Alexander Cervantes. okay, Victoria Vasquez 2B; Makayla Delgado 3-3, 2 HR; Katelyn Ochoa 3-4 2R, 3B, 2B; Elaine Sanchez 2-4. W: Mara Mazanec 2-three, 2R; Alex Gardner 2B, 2R; Faby Hernandez 3B; Natalie Granados 2-3.
Liberty-Madera Ranchos 15, Yosemite 1
Liberty (9-12, 6-0)
WP: Arianna Guzman. LP: Prater. Y, Katie Thompson 3-3; Burgess 3-3; ok. Fien 2-2; C. Duke three-5; Devine 3-5; S. Ford 2-4, 4RBI; C. Vestal three-5, 4R, HR.
TRI-RIVER ATHLETIC conference
true 6 in singles and doubles advance to the North enviornment match.
1. Daly Meinert, Clovis North d. Albertus DePlessis, Buchanan 6-1, 1-0; 3. Brodie Sodersten, Clovis d. Taka Shin, Clovis West 6-1; 5. Tommy Sesock, Clovis West d. Ethan Cardot, Clovis North 1-6, 6-2, (6-1); 7. Joel Quiroz, Clovis West d. Chris Ortiz, Clovis East 6-1, 6-2.
1. Schulz/Fourchy, Clovis North d. Castro/Sophocleous, Clovis West 6-2, 6-2; three. Bhatia/Yao, Clovis North d. Gibbons/Orozco, Clovis 7-5, 7-5; 5. Thor/Vang, Clovis East d. Vang/Vang, Clovis East 6-three, 6-4; 7. Thompson/Sever, Clovis d. Gabriel/Brunn, Clovis West 6-0, 6-0.
1. Adam Miller, Redwood d. Tony Kim, Redwood 7-5, 6-three; Matt Nudson, Golden West d. Matt Erba, Redwood eight-4; 5. Kevin Prill, El Diamante d. Ethan Cochran, El Diamante 8-6.
1. Spencer Denney/Drew Gobby, Lemoore d. Earl Magno/Colin Bresenio, Lemoore 6-3, 6-3; 3. Tyler Erba/Ian Morritse, Redwood d. Jack Brewer/Jacob Ream, El Diamante eight-6; 5. Colton Hanson/John Nguyen, Redwood d. Seth Herrera/Andrew Vadnais, Mt. Whitney 8-1.
LEIDEN, the Netherlands, Aug. 29, 2017 (GLOBE NEWSWIRE) -- ProQR Therapeutics N.V. (Nasdaq:PRQR), these days announced that dosing of cystic fibrosis sufferers in its part 1b scientific trial of QR-010 has been accomplished and true-line information are scheduled to be introduced put up-market shut on Monday, September 25, 2017.
about the PQ-010-01 part 1b medical Trial
The PQ-010-001 analyze is a part 1b, 28-day, randomized, double-blind, placebo-managed protection and tolerability trial, conducted in patients that have cystic fibrosis (CF) due to two copies of the F508del mutation (homozygotes). a total of four dose levels had been studied: 6.25, 12.5, 25 and 50mg of QR-010 in solution per dose administered by the use of inhalation. The analyze design consisted of 8 cohorts of 8 sufferers for a complete of sixty four sufferers. In each and every cohort, 6 sufferers obtained QR-010 and a couple of sufferers bought placebo. In cohorts 1-four, a single dose of QR-010 changed into administered, and in cohorts 5-eight twelve doses of QR-010 were administered over a 4-week length. sufferers protected in the examine had been adult patients with light CF sickness with a baseline expected FEV1 cost above 70%. The section 1b study is a primary-in-human trial designed to primarily investigate protection, tolerability and pharmacokinetics of QR-010. a number of exploratory efficacy endpoints are also being assessed together with sweat chloride, weight benefit, exchange in CFQ-R Respiratory Symptom rating and FEV1, however, the study is not powered for statistical significance on the exploratory efficacy endpoints.
“QR-010 has the capabilities to be an ingenious RNA therapy for patients with CF as a result of the F508del mutation. Completion of the phase 1b study is a vital step in construction, and builds upon the pre-clinical statistics and tremendous PQ-010-002 analyze where QR-010 proven an immediate impact on restoring CFTR function,” mentioned Noreen R. Henig MD, Chief clinical Officer at ProQR. “we're grateful to the patients and the medical group who participated during this early trial. ProQR is dedicated to creating meaningful RNA therapies for patients with CF.”
Following the clicking unlock saying right-line information, scheduled for put up-market shut on Monday, September 25, 2017, the business will host a convention name and webcast. The details of the convention call may be included within the press liberate and posted to the company’s web site.
About Cystic Fibrosis
Cystic fibrosis (CF) is the most common deadly inherited sickness in the Western world and influences an estimated 65,000 patients worldwide. In individuals with CF, a defective CFTR gene factors a thick, buildup of mucus in the lungs, pancreas and different organs. within the lungs, the mucus clogs the airways and traps micro organism resulting in infections, extensive lung damage and finally, respiratory failure. There isn't any cure for CF. ailment manifestations lead to a shortened lifestyles expectancy with a median age of demise of 30 years. besides the fact that children over 1,900 CF-causing gene mutations have been identified, about eighty five% of all CF patients are littered with the F508del mutation. amongst all CF sufferers, approximately 50% are homozygous for the F508del mutation.
QR-010 is a first-in-classification RNA-primarily based oligonucleotide designed to address the underlying explanation for the disease via concentrated on the mRNA in CF patients that have the F508del mutation. The F508del mutation is a deletion of three of the coding base pairs, or nucleotides, within the CFTR gene, which outcomes in the production of a misfolded CFTR protein that does not feature perpetually. QR-010 is designed to bind to the defective CFTR mRNA and to fix CFTR feature. QR-010 is designed to be self-administered by the use of an optimized eFlow® Nebulizer (PARI Pharma GmbH). eFlow® is a small, handheld aerosol delivery gadget which nebulizes QR-010 right into a mist inhaled directly into the lungs. QR-010 has been granted orphan drug designation within the united states and the european Union and fast-music reputation with the aid of the FDA. The QR-010 assignment has acquired funding from the ecu Union’s Horizon 2020 research and innovation programme beneath furnish settlement No 633545.
ProQR Therapeutics is dedicated to changing lives during the introduction of transformative RNA medicines for the remedy of severe genetic rare ailments reminiscent of cystic fibrosis, Leber’s congenital amaurosis type 10 and dystrophic epidermolysis bullosa. in response to our wonderful proprietary RNA restoration platform technologies we are growing to be our pipeline with sufferers and household in mind. *on the grounds that 2012*
This press liberate carries ahead-searching statements. All statements other than statements of historic reality are ahead-looking statements, which are sometimes indicated by way of terms akin to “expect,” “agree with,” “may,” “estimate,” “expect,” “purpose,” “intend,” “seem forward to”, “can also,” “plan,” “expertise,” “predict,” “assignment,” “should still,” “will,” “would” and identical expressions. forward-looking statements are in line with management’s beliefs and assumptions and on tips attainable to administration simplest as of the date of this press release. These forward-looking statements include, however aren't constrained to, statements related to QR-010 and the scientific development and the therapeutic talents thereof, statements regarding our ongoing and planned discovery and building of product candidates, and statements related to release of medical facts from our PQ-010-001 medical trial. Our specific consequences may differ materially from those predicted in these ahead-searching statements for a lot of causes, together with, devoid of hassle, risks linked to our medical construction actions, together with that positive effects accompanied in our prior and ongoing reviews might also now not be replicated in later trials or assure approval of any product candidate by means of regulatory authorities, manufacturing techniques and amenities, regulatory oversight, product commercialization, intellectual property claims, and the dangers, uncertainties and other components in our filings made with the Securities and exchange fee, together with certain sections of our annual file filed on form 20-F. Given these hazards, uncertainties and other elements, you should no longer location undue reliance on these forward-searching statements, and we anticipate no duty to update these ahead-looking statements, in spite of the fact that new information becomes purchasable sooner or later, except as required by using legislation.
ProQR Therapeutics N.V.:Investor Contact:Bonnie OrtegaT: +1 858 245 firstname.lastname@example.org
Media Contact:Sariette WitteT: +31 6 2970 4513 (NL)T: + 1 213 261 8891 (US)email@example.com
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Google [4 Certification Exam(s) ]
GuidanceSoftware [2 Certification Exam(s) ]
H3C [1 Certification Exam(s) ]
HDI [9 Certification Exam(s) ]
Healthcare [3 Certification Exam(s) ]
HIPAA [2 Certification Exam(s) ]
Hitachi [27 Certification Exam(s) ]
Hortonworks [1 Certification Exam(s) ]
Hospitality [2 Certification Exam(s) ]
HP [712 Certification Exam(s) ]
HR [1 Certification Exam(s) ]
HRCI [1 Certification Exam(s) ]
Huawei [20 Certification Exam(s) ]
Hyperion [10 Certification Exam(s) ]
IBM [1491 Certification Exam(s) ]
IBQH [1 Certification Exam(s) ]
ICDL [6 Certification Exam(s) ]
IEEE [1 Certification Exam(s) ]
IELTS [1 Certification Exam(s) ]
IFPUG [1 Certification Exam(s) ]
IIBA [2 Certification Exam(s) ]
IISFA [1 Certification Exam(s) ]
Informatica [2 Certification Exam(s) ]
Intel [2 Certification Exam(s) ]
IQN [1 Certification Exam(s) ]
IRS [1 Certification Exam(s) ]
ISACA [4 Certification Exam(s) ]
ISC2 [6 Certification Exam(s) ]
ISEB [24 Certification Exam(s) ]
Isilon [4 Certification Exam(s) ]
ISM [6 Certification Exam(s) ]
iSQI [7 Certification Exam(s) ]
Juniper [54 Certification Exam(s) ]
Legato [5 Certification Exam(s) ]
Liferay [1 Certification Exam(s) ]
Lotus [66 Certification Exam(s) ]
LPI [21 Certification Exam(s) ]
LSI [3 Certification Exam(s) ]
Magento [3 Certification Exam(s) ]
Maintenance [2 Certification Exam(s) ]
McAfee [8 Certification Exam(s) ]
McData [3 Certification Exam(s) ]
Medical [25 Certification Exam(s) ]
Microsoft [228 Certification Exam(s) ]
Mile2 [2 Certification Exam(s) ]
Military [1 Certification Exam(s) ]
Motorola [7 Certification Exam(s) ]
mySQL [4 Certification Exam(s) ]
Network-General [12 Certification Exam(s) ]
NetworkAppliance [35 Certification Exam(s) ]
NI [1 Certification Exam(s) ]
Nokia [2 Certification Exam(s) ]
Nortel [130 Certification Exam(s) ]
Novell [37 Certification Exam(s) ]
OMG [9 Certification Exam(s) ]
Oracle [232 Certification Exam(s) ]
P&C [1 Certification Exam(s) ]
Palo-Alto [3 Certification Exam(s) ]
PARCC [1 Certification Exam(s) ]
PayPal [1 Certification Exam(s) ]
Pegasystems [10 Certification Exam(s) ]
PEOPLECERT [4 Certification Exam(s) ]
PMI [15 Certification Exam(s) ]
Polycom [2 Certification Exam(s) ]
PostgreSQL-CE [1 Certification Exam(s) ]
Prince2 [6 Certification Exam(s) ]
PRMIA [1 Certification Exam(s) ]
PTCB [2 Certification Exam(s) ]
QAI [1 Certification Exam(s) ]
QlikView [1 Certification Exam(s) ]
Quality-Assurance [7 Certification Exam(s) ]
RACC [1 Certification Exam(s) ]
Real-Estate [1 Certification Exam(s) ]
RedHat [8 Certification Exam(s) ]
RES [5 Certification Exam(s) ]
Riverbed [8 Certification Exam(s) ]
RSA [13 Certification Exam(s) ]
Sair [8 Certification Exam(s) ]
Salesforce [3 Certification Exam(s) ]
SANS [1 Certification Exam(s) ]
SAP [78 Certification Exam(s) ]
SASInstitute [15 Certification Exam(s) ]
SAT [1 Certification Exam(s) ]
SCO [9 Certification Exam(s) ]
SCP [6 Certification Exam(s) ]
SDI [3 Certification Exam(s) ]
See-Beyond [1 Certification Exam(s) ]
Siemens [1 Certification Exam(s) ]
Snia [6 Certification Exam(s) ]
SOA [15 Certification Exam(s) ]
Social-Work-Board [1 Certification Exam(s) ]
SUN [63 Certification Exam(s) ]
SUSE [1 Certification Exam(s) ]
Sybase [17 Certification Exam(s) ]
Symantec [132 Certification Exam(s) ]
Teacher-Certification [3 Certification Exam(s) ]
The-Open-Group [8 Certification Exam(s) ]
TIA [3 Certification Exam(s) ]
Tibco [18 Certification Exam(s) ]
Trend [1 Certification Exam(s) ]
TruSecure [1 Certification Exam(s) ]
USMLE [1 Certification Exam(s) ]
VCE [5 Certification Exam(s) ]
Veeam [2 Certification Exam(s) ]
Veritas [25 Certification Exam(s) ]
Vmware [51 Certification Exam(s) ]
Wonderlic [1 Certification Exam(s) ]
XML-Master [3 Certification Exam(s) ]
Zend [5 Certification Exam(s) ]